This work is licensed under a Creative Commons Attribution 4.0 International License.
IDP-H14-A12
General Information
DRACP ID DRACP01529
Peptide Name IDP-H14-A12
Sequence RVKLVNLXFATLRAXVP
Sequence Length 17
UniProt ID Not available
PubChem CID Not available
Origin Synthetics
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| H-5B, epithelial small cell lung cancer | lung cancer | Carcinoma | EC50≈2.5 μM | MTT assay | Not available | Patent |
| NCI-H82 | Lung small cell carcinoma; Small cell lung cancer | Carcinoma | EC50≈7.5 μM | MTT assay | Not available | Patent |
| NCI-H187 | Lung small cell carcinoma; Small cell lung cancer | Carcinoma | EC50≈7.5 μM | MTT assay | Not available | Patent |
| NCI-H510A | Lung small cell carcinoma; Small cell lung cancer | Carcinoma | EC50≈7.5 μM | MTT assay | Not available | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification X=—(CH2)6—CH═CH—(CH2)3— (for the cases NS10, NS16 and Na05) links both Xs radicals in each sequence
Chiral L
Physicochemical Information
Formula C79H133N23O16
Absent amino acids CDEGHIMQSWY
Common amino acids LV
Mass 216664
Pl 12.52
Basic residues 3
Acidic residues 0
Hydrophobic residues 9
Net charge 3
Boman Index -1112
Hydrophobicity 68.82
Aliphatic Index 131.76
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US 2021/0230226 A1
Patent Title Anticancer Peptides
Other Iinformation Patent Application; Family: 8s / 8ex; Family Jurisdictions: CN, EP, CA, JP, AU, WO, US, KR; Legal Status: Pending; Application No: 201816634067; Filed: Jul 24, 2018; Published: Jul 29, 2021; Earliest Priority: Jul 25, 2017
Other Published ID AU2018305923A1 CA3070874A1 CN111263768A EP3658576A1 JP2020528458A KR20200032183A WO2019020649A1
This work is licensed under a Creative Commons Attribution 4.0 International License.