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S1
General Information
DRACP ID DRACP01590
Peptide Name S1
Sequence KKWRKWLAK
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Cationic antimicrobial peptides (CAMPs)
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | When the peptide concentrations was 50μM, the Cell survival rate(%) was 85% | MTT assay | 3 h | Patent |
| OECM-1 | Gingival squamous cell carcinoma; Squamous cell carcinoma of the oral cavity | Carcinoma | When the peptide concentrations was 50μM, the Cell survival rate(%) was 75% | MTT assay | 3 h | Patent |
| PC-9 | Lung adenocarcinoma | Carcinoma | When the peptide concentrations was 50μM, the Cell survival rate(%) was 87% | MTT assay | 3 h | Patent |
| PC-9G | Lung adenocarcinoma | Carcinoma | When the peptide concentrations was 50μM, the Cell survival rate(%) was 80% | MTT assay | 3 h | Patent |
| SAS | Tongue squamous cell carcinoma; Squamous cell carcinoma of the oral tongue | Carcinoma | When the peptide concentrations was 50μM, the Cell survival rate(%) was 1% | MTT assay | 3 h | Patent |
| PC-9 | Lung adenocarcinoma | Carcinoma | When the peptide concentrations was 50μM, the Cell survival rate(%) was 79% | MTT assay | 3 h | Patent |
| PC-9 | Lung adenocarcinoma | Carcinoma | When the peptide concentrations was 50μM, the Cell survival rate(%) was 40% | MTT assay | 12 h | Patent |
| PC-9G | Lung adenocarcinoma | Carcinoma | When the peptide concentrations was 50μM, the Cell survival rate(%) was 50% | MTT assay | 12 h | Patent |
| A549 | Lung adenocarcinoma | Carcinoma | When the peptide concentrations was 50μM, the Cell survival rate(%) was 72% | MTT assay | 12 h | Patent |
| OECM-1 | Gingival squamous cell carcinoma; Squamous cell carcinoma of the oral cavity | Carcinoma | When the peptide concentrations was 50μM, the Cell survival rate(%) was 65% | MTT assay | 12 h | Patent |
| SAS | Tongue squamous cell carcinoma; Squamous cell carcinoma of the oral tongue | Carcinoma | When the peptide concentrations was 50μM, the Cell survival rate(%) was 81% | MTT assay | 12 h | Patent |
| PC-9 | Lung adenocarcinoma | Carcinoma | When the peptide concentrations was 50μM, the Cell survival rate(%) was 79% | MTT assay | 12 h | Patent |
| PC-9 | Lung adenocarcinoma | Carcinoma | When the peptide concentrations was 50μM, the Cell survival rate(%) was 97% | MTT assay | 24 h | Patent |
| PC-9G | Lung adenocarcinoma | Carcinoma | When the peptide concentrations was 50μM, the Cell survival rate(%) was 80% | MTT assay | 24 h | Patent |
| A549 | Lung adenocarcinoma | Carcinoma | When the peptide concentrations was 50μM, the Cell survival rate(%) was 98% | MTT assay | 24 h | Patent |
| OECM-1 | Gingival squamous cell carcinoma; Squamous cell carcinoma of the oral cavity | Carcinoma | When the peptide concentrations was 50μM, the Cell survival rate(%) was 82% | MTT assay | 24 h | Patent |
| SAS | Tongue squamous cell carcinoma; Squamous cell carcinoma of the oral tongue | Carcinoma | When the peptide concentrations was 50μM, the Cell survival rate(%) was 82% | MTT assay | 24 h | Patent |
| PC-9 | Lung adenocarcinoma | Carcinoma | When the peptide concentrations was 50μM, the Cell survival rate(%) was 68% | MTT assay | 24 h | Patent |
Hemolytic Activity human red blood cells: no hemolytic activity of the peptide was found even at 800 μM
Normal (non-cancerous) Cytotoxicity human fibroblast: When the peptide concentrations was 100μM, the Cell survival rate(%) was 80%
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylization
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C61H98N18O10
Absent amino acids CDEFGHIMNPQSTVY
Common amino acids K
Mass 138644
Pl 12
Basic residues 5
Acidic residues 0
Hydrophobic residues 4
Net charge 5
Boman Index -2573
Hydrophobicity -181.11
Aliphatic Index 54.44
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 11000
Absorbance 280nm 1375
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US10093699B2
Patent Title Peptides with antimicrobial, anticancer and/or wound-healing promoting activities, pharmaceutical compositions containing the same, and use of the peptides with antimicrobial, anticancer and/or wound-healing promoting activities
Other Iinformation Granted Patent; Family: 4s / 4ex; Family Jurisdictions: TW, US; Legal Status: Active; Application No: 201615130709; Filed: Apr 15, 2016; Published: Oct 9, 2018; Earliest Priority: Nov 5, 2015; Granted: Oct 9, 2018
Other Published ID TW201716428A TWI619731B US10093699B2
This work is licensed under a Creative Commons Attribution 4.0 International License.