This work is licensed under a Creative Commons Attribution 4.0 International License.
peptide5
General Information
DRACP ID DRACP01593
Peptide Name peptide5
Sequence FLSaIVaMLGKLF
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin analogs of antimicrobial peptide temporin-SHa
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=29.5 ± 6.03 μM | MTT assay | 24 h | Patent |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50>100 μM | MTT assay | 24 h | Patent |
| NCI-H460 | Lung large cell carcinoma | Carcinoma | IC50=37.3 ± 3.5 μM | MTT assay | 24 h | Patent |
| DoHH2 | Diffuse large B-cell lymphoma germinal center B-cell type; Diffuse large B-cell lymphoma (ORDO: Orphanet_544) | Lymphoma | IC50>100 μM | MTT assay | 24 h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity NIH 3T3: IC50>100 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification a=D-alanine
Chiral Mix
Physicochemical Information
Formula C63H98N12O11S
Absent amino acids ACDEHNPQRTWY
Common amino acids L
Mass 144583
Pl 9.7
Basic residues 1
Acidic residues 0
Hydrophobic residues 7
Net charge 1
Boman Index 2402
Hydrophobicity 173.08
Aliphatic Index 142.31
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US10550155B2
Patent Title Anticancer peptides
Other Iinformation Granted Patent; Family: 2s / 2ex; Family Jurisdictions: US; Legal Status: Active; Application No: 201815937281; Filed: Mar 27, 2018; Published: Feb 4, 2020; Earliest Priority: Mar 27, 2018; Granted: Feb 4, 2020
Other Published ID US10550155B2
This work is licensed under a Creative Commons Attribution 4.0 International License.