Peptide Libraray

peptide2

General Information

DRACP ID DRACP01594

Peptide Name peptide2

Sequence FLSaIVGMLGKLF

Sequence Length 13

UniProt ID Not available

PubChem CID Not available

Origin analogs of antimicrobial peptide temporin-SHa

Type Synthetic peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
MCF-7	Invasive breast carcinoma of no special type	Carcinoma	IC50=17.9 ± 1.1 μM	MTT assay	24 h	Patent
HeLa	Human papillomavirus-related endocervical adenocarcinoma	Carcinoma	IC50>100 μM	MTT assay	24 h	Patent
NCI-H460	Lung large cell carcinoma	Carcinoma	IC50>100 μM	MTT assay	24 h	Patent

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity NIH 3T3: IC50>100 μM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer

Structure Information

PDB ID Not available

Predicted Structure Not available

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification a=D-alanine

Chiral Mix

Physicochemical Information

Formula C65H103N13O13S

Absent amino acids ACDEHNPQRTWY

Common amino acids L

Mass 152090

Pl 9.7

Basic residues 1

Acidic residues 0

Hydrophobic residues 7

Net charge 1

Boman Index 2496

Hydrophobicity 170

Aliphatic Index 142.31

Half Life
/

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 3

Amino acid distribution

Literature Information

Literature 1

Pubmed ID Not available

Title Not available

Doi Not available

Year Not available

Patent

Patent ID US10550155B2

Patent Title Anticancer peptides

Other Iinformation Granted Patent; Family: 2s / 2ex; Family Jurisdictions: US; Legal Status: Active; Application No: 201815937281; Filed: Mar 27, 2018; Published: Feb 4, 2020; Earliest Priority: Mar 27, 2018; Granted: Feb 4, 2020

Other Published ID US10550155B2