peptide4

General Information


DRACP ID  DRACP01596

Peptide Name   peptide4

Sequence  FLSGIVGMLaKLF

Sequence Length  13

UniProt ID  Not available

PubChem CID  Not available

Origin  analogs of antimicrobial peptide temporin-SHa

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
MCF-7 Invasive breast carcinoma of no special type Carcinoma IC50=16.2 ± 2.2 μM MTT assay 24 h Patent
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma IC50=22.7 ± 0.86 μM MTT assay 24 h Patent
NCI-H460 Lung large cell carcinoma Carcinoma IC50=24.3 ± 0.84 μM MTT assay 24 h Patent

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  NIH 3T3: IC50=16.02 ± 3.7 μM

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  a=D-alanine

Chiral  Mix



Physicochemical Information


Formula  C65H103N13O13S

Absent amino acids  ACDEHNPQRTWY

Common amino acids  L

Mass  152090

Pl  9.7

Basic residues  1

Acidic residues  0

Hydrophobic residues  7

Net charge  1

Boman Index  2496

Hydrophobicity  170

Aliphatic Index  142.31

Half Life 
  /

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  3

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID US10550155B2

Patent Title  Anticancer peptides

Other Iinformation  Granted Patent; Family: 2s / 2ex; Family Jurisdictions: US; Legal Status: Active; Application No: 201815937281; Filed: Mar 27, 2018; Published: Feb 4, 2020; Earliest Priority: Mar 27, 2018; Granted: Feb 4, 2020

Other Published ID  US10550155B2 




DRACP is developed by Dr.Zheng's team.