This work is licensed under a Creative Commons Attribution 4.0 International License.
peptide1
General Information
DRACP ID DRACP01597
Peptide Name peptide1
Sequence FLSGIVGMLGKLF
Sequence Length 13
UniProt ID B3KYH4
PubChem CID Not available
Origin analogs of antimicrobial peptide temporin-SHa
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=14.47 ± 0.57 μM | MTT assay | 24 h | Patent |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=18.36 ± 0.92 μM | MTT assay | 24 h | Patent |
| NCI-H460 | Lung large cell carcinoma | Carcinoma | IC50=34.49 ± 1.5 μM | MTT assay | 24 h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity NIH 3T3: IC50=73.3 ± 0.08 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C67H108N14O15S
Absent amino acids ACDEHNPQRTWY
Common amino acids GL
Mass 159597
Pl 9.7
Basic residues 1
Acidic residues 0
Hydrophobic residues 7
Net charge 1
Boman Index 2590
Hydrophobicity 166.92
Aliphatic Index 142.31
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US10550155B2
Patent Title Anticancer peptides
Other Iinformation Granted Patent; Family: 2s / 2ex; Family Jurisdictions: US; Legal Status: Active; Application No: 201815937281; Filed: Mar 27, 2018; Published: Feb 4, 2020; Earliest Priority: Mar 27, 2018; Granted: Feb 4, 2020
Other Published ID US10550155B2
This work is licensed under a Creative Commons Attribution 4.0 International License.