SHIVA DERIV P69 + KWKL

General Information


DRACP ID  DRACP01618

Peptide Name   SHIVA DERIV P69 + KWKL

Sequence  FAKKLAKKLKKLAKKLAKKWKL

Sequence Length  22

UniProt ID  Not available

PubChem CID  Not available

Origin  FLAK peptides

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
MCF-7 Invasive breast carcinoma of no special type Carcinoma LD50=44 µg/ml MTT assay 24 h Patent
SW480 Colon adenocarcinoma Carcinoma LD50=11 µg/ml MTT assay 24 h Patent
BMKC Skin carcinoma Carcinoma LD50=94 µg/ml MTT assay 24 h Patent
BMKC Skin carcinoma Carcinoma LD50=94 µg/ml MTT assay 24 h Patent
NCI-H1299 Lung large cell carcinoma Carcinoma LD50=63 µg/ml MTT assay 24 h Patent
PC-3 Prostate carcinoma Carcinoma LD50=82 µg/ml MTT assay 24 h Patent
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma LD50=28 µg/ml MTT assay 24 h Patent

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial; Antifungal



Structure Information


PDB ID  Not available

Predicted Structure  DRACP01618

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C128H228N34O23

Absent amino acids  CDEGHIMNPQRSTVY

Common amino acids  K

Mass  298621

Pl  11.8

Basic residues  11

Acidic residues  0

Hydrophobic residues  11

Net charge  11

Boman Index  -2390

Hydrophobicity  -67.27

Aliphatic Index  106.82

Half Life 
  Mammalian: 1.1 hour
  Yeast: 3 min
  E.coli: 2 min

Extinction Coefficient cystines  5500

Absorbance 280nm  261.9

Polar residues  0

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID US2005/0209157A1

Patent Title  Short bioactive peptides and methods for their use

Other Iinformation  Patent Application; Family: 1s / 24ex; Family Jurisdictions: US; Legal Status: Discontinued; Application No: 13618605; Filed: May 24, 2005; Published: Sep 22, 2005; Earliest Priority: Mar 28, 2001

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.