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SHIVA 10 (1-16)
General Information
DRACP ID DRACP01723
Peptide Name SHIVA 10 (1-16)
Sequence KTKLFKKFAKKLAKKLKKLAKKL
Sequence Length 23
UniProt ID Not available
PubChem CID Not available
Origin FLAK peptides
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| NCI-H1299 | Lung large cell carcinoma | Carcinoma | LD50=64 µg/ml | MTT assay | 24 h | Patent |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | LD50=29 µg/ml | MTT assay | 24 h | Patent |
| SW480 | Colon adenocarcinoma | Carcinoma | LD50=35 µg/ml | MTT assay | 24 h | Patent |
| BMKC | Skin carcinoma | Carcinoma | LD50=76 µg/ml | MTT assay | 24 h | Patent |
| PC-3 | Prostate carcinoma | Carcinoma | LD50=28 µg/ml | MTT assay | 24 h | Patent |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | LD50=97 µg/ml | MTT assay | 24 h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C133H241N35O25
Absent amino acids CDEGHIMNPQRSVWY
Common amino acids K
Mass 312320
Pl 11.84
Basic residues 12
Acidic residues 0
Hydrophobic residues 10
Net charge 12
Boman Index -3318
Hydrophobicity -76.09
Aliphatic Index 97.83
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US2005/0209157A1
Patent Title Short bioactive peptides and methods for their use
Other Iinformation Patent Application; Family: 1s / 24ex; Family Jurisdictions: US; Legal Status: Discontinued; Application No: 13618605; Filed: May 24, 2005; Published: Sep 22, 2005; Earliest Priority: Mar 28, 2001
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.