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pDBD * 4R9
General Information
DRACP ID DRACP01752
Peptide Name pDBD * 4R9
Sequence YLCAGRNDCIIAIKFEEKTAQHAAIENVFRLERRRRRRRRR
Sequence Length 41
UniProt ID Not available
PubChem CID Not available
Origin Synthetics
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| ICR27-4 | Human leukemic | Leukemia | As show in fig1, data show a significant anticancer effect | WST-1 assay | 4 h | Patent |
| CCRF-CEM | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | As show in fig1, data show a significant anticancer effect | WST-1 assay | 4 h | Patent |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | As show in fig1, data show a significant anticancer effect | WST-1 assay | 4 h | Patent |
| CaCo-2 | Colon adenocarcinoma | Carcinoma | As show in fig1, data show a significant anticancer effect | WST-1 assay | 4 h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity NIH 3T3: Barely toxic
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C216H365N81O57S2
Absent amino acids MPSW
Common amino acids R
Mass 578655
Pl 11.89
Basic residues 14
Acidic residues 5
Hydrophobic residues 14
Net charge 9
Boman Index -18530
Hydrophobicity -101.22
Aliphatic Index 76.34
Half Life
Mammalian: 2.8 hour
Yeast: 10 min
E.coli: 2 min
Extinction Coefficient cystines 1615
Absorbance 280nm 40.38
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US2006/0100147A1
Patent Title Anticancer peptide
Other Iinformation Patent Application; Family: 2s / 2ex; Family Jurisdictions: US; Legal Status: Discontinued; Application No: 23095205; Filed: Sep 19, 2005; Published: May 11, 2006; Earliest Priority: Sep 20, 2004
Other Published ID US2009203594A1
This work is licensed under a Creative Commons Attribution 4.0 International License.