This work is licensed under a Creative Commons Attribution 4.0 International License.
DDA-DL6R6-25
General Information
DRACP ID DRACP01754
Peptide Name DDA-DL6R6-25
Sequence lRRllRRllRRl
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| 22Rv1 | Prostate carcinoma | Carcinoma | LC50=3.125 µM | MTT assay | Not available | Patent |
| CL1 | Prostate carcinoma | Carcinoma | LC50=3.125 µM | MTT assay | Not available | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity NIH 3T3: LC50=100 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification CH3(CH2)10CO, Dodecanoic acid
C-terminal Modification Amidation
Other Modification l=D-Leucine
Chiral Mix
Physicochemical Information
Formula C36H62N24O
Absent amino acids ACDEFGHIKLMNPQSTVWY
Common amino acids R
Mass 104340
Pl 13.2
Basic residues 6
Acidic residues 0
Hydrophobic residues 0
Net charge 6
Boman Index -8952
Hydrophobicity -225
Aliphatic Index 0
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US2007/0072808A1
Patent Title Antimicrobial and anticancer lipopeptides
Other Iinformation Patent Application; Family: 11s / 13ex; Family Jurisdictions: EP, US, AU, WO, CA; Legal Status: Active; Application No: 56072704; Filed: Jun 18, 2004; Published: Mar 29, 2007; Earliest Priority: Jun 19, 2003; Granted: Mar 2, 2010
Other Published ID AU2004246909A1 AU2004246909B2 CA2529125A1 EP1633380A2 EP1633380A4 US2010160213A1 US7671011B2 US8445636B2 WO2004110341A2 WO2004110341A3
External Code
This work is licensed under a Creative Commons Attribution 4.0 International License.