This work is licensed under a Creative Commons Attribution 4.0 International License.
DL6K6
General Information
DRACP ID DRACP01755
Peptide Name DL6K6
Sequence lKKllKKllKKl
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| 22Rv1 | Prostate carcinoma | Carcinoma | LC50>100 µM | MTT assay | Not available | Patent |
| CL1 | Prostate carcinoma | Carcinoma | LC50>100 µM | MTT assay | Not available | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity NIH 3T3: LC50=>100 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification l=D-Leucine
Chiral Mix
Physicochemical Information
Formula C36H62N12O
Absent amino acids ACDEFGHILMNPQRSTVWY
Common amino acids K
Mass 87534
Pl 11.5
Basic residues 6
Acidic residues 0
Hydrophobic residues 0
Net charge 6
Boman Index -3330
Hydrophobicity -195
Aliphatic Index 0
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US2007/0072808A1
Patent Title Antimicrobial and anticancer lipopeptides
Other Iinformation Patent Application; Family: 11s / 13ex; Family Jurisdictions: EP, US, AU, WO, CA; Legal Status: Active; Application No: 56072704; Filed: Jun 18, 2004; Published: Mar 29, 2007; Earliest Priority: Jun 19, 2003; Granted: Mar 2, 2010
Other Published ID AU2004246909A1 AU2004246909B2 CA2529125A1 EP1633380A2 EP1633380A4 US2010160213A1 US7671011B2 US8445636B2 WO2004110341A2 WO2004110341A3
This work is licensed under a Creative Commons Attribution 4.0 International License.