Peptide Libraray

PA-DL6K6-24

General Information

DRACP ID DRACP01757

Peptide Name PA-DL6K6-24

Sequence lKKllKKllKKl

Sequence Length 12

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
22Rv1	Prostate carcinoma	Carcinoma	LC50<3.125 µM	MTT assay	Not available	Patent
CL1	Prostate carcinoma	Carcinoma	LC50=3.125 µM	MTT assay	Not available	Patent

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity NIH 3T3: LC50=50 μM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antimicrobial; Antifungal

Structure Information

PDB ID Not available

Predicted Structure Not available

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification CH3(CH2)14CO, Palmitic acid

C-terminal Modification Amidation

Other Modification l=D-Leucine

Chiral Mix

Physicochemical Information

Formula C36H62N12O

Absent amino acids ACDEFGHILMNPQRSTVWY

Common amino acids K

Mass 87534

Pl 11.5

Basic residues 6

Acidic residues 0

Hydrophobic residues 0

Net charge 6

Boman Index -3330

Hydrophobicity -195

Aliphatic Index 0

Half Life
/

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 0

Amino acid distribution

Literature Information

Literature 1

Pubmed ID Not available

Title Not available

Doi Not available

Year Not available

Patent

Patent ID US2007/0072808A1

Patent Title Antimicrobial and anticancer lipopeptides

Other Iinformation Patent Application; Family: 11s / 13ex; Family Jurisdictions: EP, US, AU, WO, CA; Legal Status: Active; Application No: 56072704; Filed: Jun 18, 2004; Published: Mar 29, 2007; Earliest Priority: Jun 19, 2003; Granted: Mar 2, 2010

Other Published ID AU2004246909A1 AU2004246909B2 CA2529125A1 EP1633380A2 EP1633380A4 US2010160213A1 US7671011B2 US8445636B2 WO2004110341A2 WO2004110341A3