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IDP-LS17
General Information
DRACP ID DRACP01771
Peptide Name IDP-LS17
Sequence APKVVILXKALEYLXA
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Synthetics
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | EC50>100 μM | MTT assay | Not available | Patent |
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | EC50>100 μM | MTT assay | Not available | Patent |
| RPMI | Human multiple myeloma | Carcinoma | EC50≈10 μM | MTT assay | Not available | Patent |
| U266B1 | Plasma cell myeloma; Multiple myeloma | Carcinoma | EC50≈16 μM | MTT assay | Not available | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification X=—(CH2)6—CH═CH—(CH2)3— (for the cases NS10, NS16 and Na05) links both Xs radicals in each sequence
Chiral L
Physicochemical Information
Formula C74H122N16O16
Absent amino acids CDFGHMNQRSTW
Common amino acids AL
Mass 197963
Pl 9.26
Basic residues 2
Acidic residues 1
Hydrophobic residues 9
Net charge 1
Boman Index 1514
Hydrophobicity 96.88
Aliphatic Index 152.5
Half Life
/
Extinction Coefficient cystines 1490
Absorbance 280nm 99.33
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US2020/0157150A1
Patent Title Anticancer Peptides
Other Iinformation Patent Application; Family: 8s / 8ex; Family Jurisdictions: CA, CN, US, AU, JP, EP, WO, KR; Legal Status: Pending; Application No: 201816635902; Filed: Jul 31, 2018; Published: May 21, 2020; Earliest Priority: Aug 1, 2017
Other Published ID AU2018311129A1 CA3071601A1 CN111436200A EP3661947A1 JP2020529429A KR20200032730A WO2019025432A1
This work is licensed under a Creative Commons Attribution 4.0 International License.