IDP-LS16

General Information


DRACP ID  DRACP01772

Peptide Name   IDP-LS16

Sequence  APKVVXLSKALEXLQA

Sequence Length  16

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetics

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
MCF-7 Invasive breast carcinoma of no special type Carcinoma EC50>100 μM MTT assay Not available Patent
HL-60 Adult acute myeloid leukemia; Acute myeloid leukemia Leukemia EC50>100 μM MTT assay Not available Patent
RPMI Human multiple myeloma Carcinoma EC50≈15 μM MTT assay Not available Patent
U266B1 Plasma cell myeloma; Multiple myeloma Carcinoma EC50≈10 μM MTT assay Not available Patent

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antitumor



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  X=—(CH2)6—CH═CH—(CH2)3— (for the cases NS10, NS16 and Na05) links both Xs radicals in each sequence

Chiral  L



Physicochemical Information


Formula  C67H115N17O17

Absent amino acids  CDFGHIMNRTWY

Common amino acids  AL

Mass  191850

Pl  9.54

Basic residues  2

Acidic residues  1

Hydrophobic residues  8

Net charge  1

Boman Index  142

Hydrophobicity  50

Aliphatic Index  128.13

Half Life 
  /

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  1

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID US2020/0157150A1

Patent Title  Anticancer Peptides

Other Iinformation  Patent Application; Family: 8s / 8ex; Family Jurisdictions: CA, CN, US, AU, JP, EP, WO, KR; Legal Status: Pending; Application No: 201816635902; Filed: Jul 31, 2018; Published: May 21, 2020; Earliest Priority: Aug 1, 2017

Other Published ID  AU2018311129A1  CA3071601A1  CN111436200A  EP3661947A1  JP2020529429A  KR20200032730A  WO2019025432A1 




DRACP is developed by Dr.Zheng's team.