This work is licensed under a Creative Commons Attribution 4.0 International License.
IDP-intwtL05
General Information
DRACP ID DRACP01782
Peptide Name IDP-intwtL05
Sequence RRRRRRRRKRRNDLRSRFLALRDQ
Sequence Length 24
UniProt ID Not available
PubChem CID Not available
Origin Synthetics
Type Synthetic peptide
Classification
Active ACP Stapled Peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | EC50>100 μM | MTT assay | Not available | Patent |
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | EC50>100 μM | MTT assay | Not available | Patent |
| RPMI | Human multiple myeloma | Carcinoma | EC50>100 μM | MTT assay | Not available | Patent |
| U266B1 | Plasma cell myeloma; Multiple myeloma | Carcinoma | EC50>100 μM | MTT assay | Not available | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C134H246N66O32
Absent amino acids CEGHIMPTVWY
Common amino acids R
Mass 370424
Pl 13.02
Basic residues 14
Acidic residues 2
Hydrophobic residues 5
Net charge 12
Boman Index -21298
Hydrophobicity -255
Aliphatic Index 52.92
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID CN111511761A
Patent Title Anticancer Peptides
Other Iinformation Patent Application; Family: 8s / 8ex; Family Jurisdictions: CA, CN, US, AU, JP, EP, WO, KR; Legal Status: Pending; Application No: 201816635902; Filed: Jul 31, 2018; Published: May 21, 2020; Earliest Priority: Aug 1, 2017
Other Published ID AU2018311129A1 CA3071601A1 CN111436200A EP3661947A1 JP2020529429A KR20200032730A WO2019025432A1
This work is licensed under a Creative Commons Attribution 4.0 International License.