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NLCa02
General Information
DRACP ID DRACP01783
Peptide Name NLCa02
Sequence RRRRRRRRQRRNDLRSSFLTLRDHVP
Sequence Length 26
UniProt ID P18444 P03966 Q63379 Q61976 P24793 P04198 P26014
PubChem CID Not available
Origin Synthetics
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| RG1, epithelial (glioblastoma, GMB), from surgical specimens from patients | Glioblastoma | Blastoma | EC50≈5 μM | CYTELL assay | 72-96 h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification CPP2 corresponds to penetratine peptide.
Chiral L
Physicochemical Information
Formula C142H252N66O36
Absent amino acids ACEGIKMWY
Common amino acids R
Mass 390604
Pl 12.98
Basic residues 13
Acidic residues 2
Hydrophobic residues 5
Net charge 11
Boman Index -20091
Hydrophobicity -218.08
Aliphatic Index 56.15
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US2020/0157150A1
Patent Title Anticancer Peptides
Other Iinformation Patent Application; Family: 8s / 8ex; Family Jurisdictions: CA, CN, US, AU, JP, EP, WO, KR; Legal Status: Pending; Application No: 201816635902; Filed: Jul 31, 2018; Published: May 21, 2020; Earliest Priority: Aug 1, 2017
Other Published ID AU2018311129A1 CA3071601A1 CN111436200A EP3661947A1 JP2020529429A KR20200032730A WO2019025432A1
This work is licensed under a Creative Commons Attribution 4.0 International License.