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IDP-LLCb02
General Information
DRACP ID DRACP01786
Peptide Name IDP-LLCb02
Sequence RRRRRRRSKAPKVVILSKALEYLQA
Sequence Length 25
PubChem CID Not available
Origin Synthetics
Type Synthetic peptide
Classification
Active ACP Stapled Peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| NCI-H187 | Lung small cell carcinoma; Small cell lung cancer | Carcinoma | EC50≈7.5 μM | MTT assay | Not available | Patent |
| NCI-H82 | Lung small cell carcinoma; Small cell lung cancer | Carcinoma | EC50≈10 μM | MTT assay | Not available | Patent |
| NCI-H510A | Lung small cell carcinoma; Small cell lung cancer | Carcinoma | EC50≈15 μM | MTT assay | Not available | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Cyclic(stapled)
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification CPP2 corresponds to penetratine peptide.
Chiral L
Physicochemical Information
Formula C133H240N50O32
Absent amino acids CDFGHMNTW
Common amino acids R
Mass 347993
Pl 12.64
Basic residues 10
Acidic residues 1
Hydrophobic residues 9
Net charge 9
Boman Index -10719
Hydrophobicity -100
Aliphatic Index 97.6
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 1490
Absorbance 280nm 62.08
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID CN111511761A
Patent Title Anticancer Peptides
Other Iinformation Patent Application; Family: 8s / 8ex; Family Jurisdictions: CA, CN, US, AU, JP, EP, WO, KR; Legal Status: Pending; Application No: 201816635902; Filed: Jul 31, 2018; Published: May 21, 2020; Earliest Priority: Aug 1, 2017
Other Published ID AU2018311129A1 CA3071601A1 CN111436200A EP3661947A1 JP2020529429A KR20200032730A WO2019025432A1
This work is licensed under a Creative Commons Attribution 4.0 International License.