IDP-Lb03

General Information


DRACP ID  DRACP01791

Peptide Name   IDP-Lb03

Sequence  SKXPKVVILXKALEYL

Sequence Length  16

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetics

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
NCI-H187 Lung small cell carcinoma; Small cell lung cancer Carcinoma EC50≈22.5 μM MTT assay Not available Patent
NCI-H82 Lung small cell carcinoma; Small cell lung cancer Carcinoma EC50≈5 μM MTT assay Not available Patent
NCI-H510A Lung small cell carcinoma; Small cell lung cancer Carcinoma EC50≈15 μM MTT assay Not available Patent

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antitumor



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  X=—(CH2)6—CH═CH—(CH2)3— (for the cases NS10, NS16 and Na05) links both Xs radicals in each sequence

Chiral  L



Physicochemical Information


Formula  C77H129N17O17

Absent amino acids  CDFGHMNQRTW

Common amino acids  KL

Mass  205271

Pl  10.12

Basic residues  3

Acidic residues  1

Hydrophobic residues  7

Net charge  2

Boman Index  257

Hydrophobicity  45

Aliphatic Index  140

Half Life 
  /

Extinction Coefficient cystines  1490

Absorbance 280nm  99.33

Polar residues  2

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID US2020/0157150A1

Patent Title  Anticancer Peptides

Other Iinformation  Patent Application; Family: 8s / 8ex; Family Jurisdictions: CA, CN, US, AU, JP, EP, WO, KR; Legal Status: Pending; Application No: 201816635902; Filed: Jul 31, 2018; Published: May 21, 2020; Earliest Priority: Aug 1, 2017

Other Published ID  AU2018311129A1  CA3071601A1  CN111436200A  EP3661947A1  JP2020529429A  KR20200032730A  WO2019025432A1 




DRACP is developed by Dr.Zheng's team.