This work is licensed under a Creative Commons Attribution 4.0 International License.
Synthetic peptide
General Information
DRACP ID DRACP01794
Peptide Name Synthetic peptide
Sequence KWKKLLKKPPPLLKKLLKKL
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Calu-6 | Lung adenocarcinoma | Carcinoma | 35% survival rate at 10 µM | MTT assay | Not available | Patent |
| Calu-6 | Lung adenocarcinoma | Carcinoma | 0% survival rate at 100 µM | MTT assay | Not available | Patent |
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | ~60% survival rate at 10 µM | MTT assay | Not available | Patent |
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | 0% survival rate at 100 µM | MTT assay | Not available | Patent |
| SNU-601 | Gastric signet ring cell adenocarcinoma | Carcinoma | ~20% survival rate at 10 µM | MTT assay | Not available | Patent |
| SNU-601 | Gastric signet ring cell adenocarcinoma | Carcinoma | 0% survival rate at 100 µM | MTT assay | Not available | Patent |
Hemolytic Activity no haemolytic activity
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C122H218N30O21
Absent amino acids ACDEFGHIMNQRSTVY
Common amino acids K
Mass 278035
Pl 11.7
Basic residues 9
Acidic residues 0
Hydrophobic residues 8
Net charge 9
Boman Index -1318
Hydrophobicity -71
Aliphatic Index 136.5
Half Life
Mammalian:
Yeast:
E.coli:
Extinction Coefficient cystines 5500
Absorbance 280nm 289.47
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US6800727B2
Patent Title Peptides with increased + charge and hydrophobicity by substituting one or more amino acids of CA-MA peptide and pharmaceutical compositions containing thereof
Other Iinformation Granted Patent; Family: 4s / 4ex; Family Jurisdictions: KR, US; Legal Status: Expired; Application No: 8141802; Filed: Feb 22, 2002; Published: Oct 5, 2004; Earliest Priority: Sep 19, 2001; Granted: Oct 5, 2004
Other Published ID KR100438416B1 KR20030024961A US6800727B2
This work is licensed under a Creative Commons Attribution 4.0 International License.