SEQ ID NO: 10

General Information


DRACP ID  DRACP01798

Peptide Name   SEQ ID NO: 10

Sequence  LMYXYLK

Sequence Length  7

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetics

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
PA-1 Ovarian mixed germ cell tumor; Mixed germ cell tumor Germ cell tumor When the peptide concentrations were 1 nM, 10 nM, 100 nM, and 1 μM, the Percent Cytotoxicity of the tumor was 37.5 ± 3.8, 32.0 ± 2.9, 31.0 ± 2.7, 28.4 ± 2.2 MTT assay 48 h Patent
PTC Papillary thyroid carcinoma Carcinoma When the peptide concentrations were 1 nM, 10 nM, 100 nM, and 1 μM, the Percent Cytotoxicity of the tumor was 30.5 ± 3.2, 28.0 ± 2.2, 25.6 ± 2.2, 21.8 ± 2.8 MTT assay 48 h Patent
HEp-2 Human papillomavirus-related endocervical adenocarcinoma Carcinoma When the peptide concentrations were 1 nM, 10 nM, 100 nM, and 1 μM, the Percent Cytotoxicity of the tumor was 35.4 ± 2.9, 32.0 ± 2.1, 31.8 ± 3.1, 28.9 ± 2.1 MTT assay 48 h Patent
Mia PaCa-2 Pancreatic ductal adenocarcinoma Carcinoma When the peptide concentrations were 1 nM, 10 nM, 100 nM, and 1 μM, the Percent Cytotoxicity of the tumor was 14.9 ± 1.9, 12.0 ± 1.7, 9.0 ± 0.6, MTT assay 48 h Patent
KB Human papillomavirus-related endocervical adenocarcinoma Carcinoma When the peptide concentrations were 1 nM, 10 nM, 100 nM, and 1 μM, the Percent Cytotoxicity of the tumor was 32.0 ± 2.5, 31.9 ± 2.9, 29.6 ± 0.7, 26.0 ± 1.8 MTT assay 48 h Patent
ECV-304 Bladder carcinoma Carcinoma When the peptide concentrations were 1 nM, 10 nM, 100 nM, the Percent Cytotoxicity of the tumor was 15.2 ± 1.0, 12.9 ± 0.5, 9.4 ± 0.2 MTT assay 48 h Patent

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  X=Saa1=furanoid sugar amino acid

Chiral  L



Physicochemical Information


Formula  C41H61N7O8S

Absent amino acids  ACDEFGHINPQRSTVW

Common amino acids  LY

Mass  102924

Pl  9.15

Basic residues  1

Acidic residues  0

Hydrophobic residues  2

Net charge  1

Boman Index  636

Hydrophobicity  42.86

Aliphatic Index  111.43

Half Life 
  /

Extinction Coefficient cystines  2980

Absorbance 280nm  496.67

Polar residues  2

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID US7060678B2

Patent Title  Peptides comprising furanoid sugar amino acids for the treatment of cancer

Other Iinformation  Granted Patent; Family: 2s / 2ex; Family Jurisdictions: US; Legal Status: Inactive; Application No: 63810703; Filed: Aug 8, 2003; Published: Jun 13, 2006; Earliest Priority: Aug 8, 2003; Granted: Jun 13, 2006

Other Published ID  US7060678B2 




DRACP is developed by Dr.Zheng's team.