Gaegurin peptides SEQID NO: 1

General Information


DRACP ID  DRACP01805

Peptide Name   Gaegurin peptides SEQID NO: 1

Sequence  FLGWLFKWAKK

Sequence Length  11

UniProt ID  Not available

PubChem CID  Not available

Origin  Korean frog Rana rugosa

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
SK-MEL-2 Melanoma Carcinoma IC50=27.39 mM MTT assay 24 h Patent
A549 Lung adenocarcinoma Carcinoma IC50=25.2 mM MTT assay 24 h Patent
SK-N-DZ Neuroblastoma Blastoma IC50=24.76 mM MTT assay 24 h Patent
MKN45 Gastric adenocarcinoma Carcinoma IC50=26.7 mM MTT assay 24 h Patent
PC-3 Prostate carcinoma Carcinoma IC50=47.69 mM MTT assay 24 h Patent
A498 Renal cell carcinoma Carcinoma IC50=41.21 mM MTT assay 24 h Patent
HCT 116 Colon carcinoma Carcinoma IC50=27 mM MTT assay 24 h Patent
NCI-H630 Rectal carcinoma Carcinoma Not available MTT assay 24 h Patent

Hemolytic Activity  non-hemolytic activity

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antimicrobial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP01805

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C75H106N16O12

Absent amino acids  CDEHIMNPQRSTVY

Common amino acids  K

Mass  160232

Pl  11.1

Basic residues  3

Acidic residues  0

Hydrophobic residues  7

Net charge  3

Boman Index  656

Hydrophobicity  10

Aliphatic Index  80

Half Life 
  Mammalian: 30 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  11000

Absorbance 280nm  1100

Polar residues  1

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID US8076284B2

Patent Title  Analogues of antimicrobial and anticancer peptide synthesized and produced from Gaegurin 5

Other Iinformation  Granted Patent; Family: 9s / 9ex; Family Jurisdictions: EP, KR, US, WO, JP, CN; Legal Status: Active; Application No: 30102807; Filed: May 14, 2007; Published: Dec 13, 2011; Earliest Priority: May 16, 2006; Granted: Dec 13, 2011

Other Published ID  CN101443352A  EP2016094A1  EP2016094A4  JP2009537511A  KR100794499B1  KR20070111027A  US8076284B2  WO2007133033A1 




DRACP is developed by Dr.Zheng's team.