This work is licensed under a Creative Commons Attribution 4.0 International License.
Gaegurin peptides SEQID NO: 4
General Information
DRACP ID DRACP01808
Peptide Name Gaegurin peptides SEQID NO: 4
Sequence FLWWLFKWAWK
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Korean frog Rana rugosa
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| SK-MEL-2 | Melanoma | Carcinoma | IC50=13.16 mM | MTT assay | 24 h | Patent |
| A549 | Lung adenocarcinoma | Carcinoma | IC50=14.8 mM | MTT assay | 24 h | Patent |
| SK-N-DZ | Neuroblastoma | Blastoma | IC50=14.58 mM | MTT assay | 24 h | Patent |
| MKN45 | Gastric adenocarcinoma | Carcinoma | IC50=13.77 mM | MTT assay | 24 h | Patent |
| PC-3 | Prostate carcinoma | Carcinoma | IC50=24.32 mM | MTT assay | 24 h | Patent |
| A498 | Renal cell carcinoma | Carcinoma | Not available | MTT assay | 24 h | Patent |
| HCT 116 | Colon carcinoma | Carcinoma | IC50=14.8 mM | MTT assay | 24 h | Patent |
| NCI-H630 | Rectal carcinoma | Carcinoma | IC50=57 mM | MTT assay | 24 h | Patent |
Hemolytic Activity non-hemolytic activity
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C89H111N17O12
Absent amino acids CDEGHIMNPQRSTVY
Common amino acids W
Mass 178952
Pl 10.81
Basic residues 2
Acidic residues 0
Hydrophobic residues 9
Net charge 2
Boman Index 1583
Hydrophobicity 32.73
Aliphatic Index 80
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 22000
Absorbance 280nm 2200
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US8076284B2
Patent Title Analogues of antimicrobial and anticancer peptide synthesized and produced from Gaegurin 5
Other Iinformation Granted Patent; Family: 9s / 9ex; Family Jurisdictions: EP, KR, US, WO, JP, CN; Legal Status: Active; Application No: 30102807; Filed: May 14, 2007; Published: Dec 13, 2011; Earliest Priority: May 16, 2006; Granted: Dec 13, 2011
Other Published ID CN101443352A EP2016094A1 EP2016094A4 JP2009537511A KR100794499B1 KR20070111027A US8076284B2 WO2007133033A1
This work is licensed under a Creative Commons Attribution 4.0 International License.