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GK-3
General Information
DRACP ID DRACP01814
Peptide Name GK-3
Sequence RWRLFKRIGIGRLLKRGLR
Sequence Length 19
UniProt ID Not available
PubChem CID Not available
Origin AMPs
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | IC50=13 μg/ml | MTT assay | Not available | Patent |
| BCaP-37 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=25 μg/ml | MTT assay | Not available | Patent |
| QGY-7703 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=21 μg/ml | MTT assay | Not available | Patent |
| LoVo | Colon adenocarcinoma | Carcinoma | IC50=31 μg/ml | MTT assay | Not available | Patent |
Hemolytic Activity Human red blood cells: When the concentration of peptide is 12.5, 25, 50, 100, 200 and 500 μg/ml, the hemolysis rate (%) is 0%, 0%, 0.6%, 1.1% and 1.9%, respectively.
Normal (non-cancerous) Cytotoxicity Mouse NH-3T3: IC50>100 μg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C110H192N40O20
Absent amino acids ACDEHMNPQSTVY
Common amino acids R
Mass 271623
Pl 13.2
Basic residues 8
Acidic residues 0
Hydrophobic residues 8
Net charge 8
Boman Index -6297
Hydrophobicity -52.11
Aliphatic Index 123.16
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 305.56
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID WO2004/020461A1
Patent Title A Group of Novel Synthetic Antibiotic Peptides
Other Iinformation Patent Application; Family: 10s / 10ex; Family Jurisdictions: US, AU, CN, EP, AT, WO; Legal Status: Pending; Application No: 0300522; Filed: Jul 1, 2003; Published: Mar 11, 2004; Earliest Priority: Sep 2, 2002
Other Published ID AT528316T AU2003293296A1 CN1269837C CN1398897A EP1541584A1 EP1541584A4 EP1541584B1 US2008070279A1 US7629438B2
This work is licensed under a Creative Commons Attribution 4.0 International License.