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Gaegurin peptides SEQID NO: 4
General Information
DRACP ID DRACP01818
Peptide Name Gaegurin peptides SEQID NO: 4
Sequence FLWWLFKWAWK
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Korean frog Rana rugosa
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A498 | Renal cell carcinoma | Carcinoma | IC50=NAmM | MTT assay | 24 h | Patent |
| A549 | Lung adenocarcinoma | Carcinoma | IC50=15.88mM | MTT assay | 24 h | Patent |
| HCT 116 | Colon carcinoma | Carcinoma | IC50=14.8mM | MTT assay | 24 h | Patent |
| MKN45 | Gastric adenocarcinoma | Carcinoma | IC50=13.77mM | MTT assay | 24 h | Patent |
| NCI-H630 | Rectal carcinoma | Carcinoma | IC50=57mM | MTT assay | 24 h | Patent |
| PC-3 | Prostate carcinoma | Carcinoma | IC50=24.32mM | MTT assay | 24 h | Patent |
| SK-MEL-2 | Melanoma | Carcinoma | IC50=13.16mM | MTT assay | 24 h | Patent |
| SK-N-DZ | Neuroblastoma | Blastoma | IC50=14.58mM | MTT assay | 24 h | Patent |
Hemolytic Activity Human red blood cells: Hemolysis values (%)=19.37, peptide concentration is 100mg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C89H111N17O12
Absent amino acids CDEGHIMNPQRSTVY
Common amino acids W
Mass 178952
Pl 10.81
Basic residues 2
Acidic residues 0
Hydrophobic residues 9
Net charge 2
Boman Index 1583
Hydrophobicity 32.73
Aliphatic Index 80
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 22000
Absorbance 280nm 2200
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID WO2007133033A1
Patent Title Novel Analogues of Antimicrobial and Anticancer Peptide Synthesized and Produced From Gaegurin 5
Other Iinformation Patent Application; Family: 9s / 9ex; Family Jurisdictions: EP, KR, US, WO, JP, CN; Legal Status: Pending; Application No: 2007002358; Filed: May 14, 2007; Published: Nov 22, 2007; Earliest Priority: May 16, 2006
Other Published ID CN101443352A EP2016094A1 EP2016094A4 JP2009537511A KR100794499B1 KR20070111027A US2010105626A1 US8076284B2
This work is licensed under a Creative Commons Attribution 4.0 International License.