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Not available
General Information
DRACP ID DRACP01819
Peptide Name Not available
Sequence KAMKSIAKFIAK
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Synthetics
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | At the concentration of 40umol/L, 20umol/L and 5umol/L, the peptide can inhibit more than 80% of HeLa cells | MTT assay | Not available | Patent |
Hemolytic Activity 37% of red blood cells lysed at 200umol
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C62H110N16O14S
Absent amino acids CDEGHLNPQRTVWY
Common amino acids K
Mass 153211
Pl 11.28
Basic residues 4
Acidic residues 0
Hydrophobic residues 6
Net charge 4
Boman Index -500
Hydrophobicity 22.5
Aliphatic Index 90
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID WO2009/015602A1
Patent Title Polypeptides Having Anticancer Activity
Other Iinformation Patent Application; Family: 10s / 10ex; Family Jurisdictions: WO, CN, EP, JP, US; Legal Status: Pending; Application No: 2008071804; Filed: Jul 30, 2008; Published: Feb 5, 2009; Earliest Priority: Jul 31, 2007
Other Published ID CN100590130C CN101168563A EP2184295A1 EP2184295A4 EP2184295B1 JP2010534689A JP5707594B2 US2010145012A1 US8207122B2
This work is licensed under a Creative Commons Attribution 4.0 International License.