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Not available
General Information
DRACP ID DRACP01822
Peptide Name Not available
Sequence RKGWFKAMKSIAKFIAKEKLKEHL
Sequence Length 24
UniProt ID Not available
PubChem CID Not available
Origin Synthetics
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HT-1080 | Fibrosarcoma | Sarcoma | When the peptide concentration is 40μmol/L, the cell growth inhibition rate is about 0.97. | MTT assay | Not available | Patent |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | When the peptide concentration is 40μmol/L, the cell growth inhibition rate is about 0.9. | MTT assay | Not available | Patent |
| HNE-1 | Nasopharyngeal carcinoma; Nasopharyngeal carcinoma | Carcinoma | When the peptide concentration is 40μmol/L, the cell growth inhibition rate is about 0.6. | MTT assay | Not available | Patent |
| CNE-1 | Breast cancer | Carcinoma | When the peptide concentration is 40μmol/L, the cell growth inhibition rate is about 0.58. | MTT assay | Not available | Patent |
| JB6 | Human anaplastic large cell lymphoma | Lymphoma | When the peptide concentration is 40μmol/L, the cell growth inhibition rate is about 0.38. | MTT assay | Not available | Patent |
Hemolytic Activity 19% of red blood cells lysed at 200umol
Normal (non-cancerous) Cytotoxicity There were no notable toxic effects (within 48 hours) from subcutaneous injection into mice at 200 mg /kg body weight
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C136H223N37O30S
Absent amino acids CDNPQTVY
Common amino acids K
Mass 329899
Pl 11.18
Basic residues 9
Acidic residues 2
Hydrophobic residues 10
Net charge 7
Boman Index -3876
Hydrophobicity -60.83
Aliphatic Index 77.5
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 239.13
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID WO2009/015602A1
Patent Title Polypeptides Having Anticancer Activity
Other Iinformation Patent Application; Family: 10s / 10ex; Family Jurisdictions: WO, CN, EP, JP, US; Legal Status: Pending; Application No: 2008071804; Filed: Jul 30, 2008; Published: Feb 5, 2009; Earliest Priority: Jul 31, 2007
Other Published ID CN100590130C CN101168563A EP2184295A1 EP2184295A4 EP2184295B1 JP2010534689A JP5707594B2 US2010145012A1 US8207122B2
This work is licensed under a Creative Commons Attribution 4.0 International License.