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N10K
General Information
DRACP ID DRACP01826
Peptide Name N10K
Sequence NQVSLTCLVK
Sequence Length 10
UniProt ID Not available
PubChem CID Not available
Origin AMPs
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| B16-F10-Nex2 | Mouse melanoma | Carcinoma | As shown in fig. 6, the peptide has anticancer activity | Trypan Blue exclusion assay | 12 h | Patent |
| SK-MEL-28 | Cutaneous melanoma | Carcinoma | As shown in fig. 6, the peptide has anticancer activity | Trypan Blue exclusion assay | 12 h | Patent |
| SK-MEL-25 | Melanoma | Carcinoma | As shown in fig. 6, the peptide has anticancer activity | Trypan Blue exclusion assay | 12 h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antiviral
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C47H85N13O15S
Absent amino acids ADEFGHIMPRWY
Common amino acids LV
Mass 126505
Pl 8.55
Basic residues 1
Acidic residues 0
Hydrophobic residues 4
Net charge 1
Boman Index -450
Hydrophobicity 61
Aliphatic Index 136
Half Life
Mammalian: 2.8 hour
Yeast: 10 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID WO2011/060393A1
Patent Title Antimicrobial, Antiviral, Anticancer and Immunomodulatory Peptides and Uses Therefore
Other Iinformation Patent Application; Family: 1s / 1ex; Family Jurisdictions: WO; Legal Status: Pending; Application No: 2010056763; Filed: Nov 15, 2010; Published: May 19, 2011; Earliest Priority: Nov 16, 2009
Other Published ID US20090261738P20091116
This work is licensed under a Creative Commons Attribution 4.0 International License.