This work is licensed under a Creative Commons Attribution 4.0 International License.
PIER4 (Tat-PIER1)
General Information
DRACP ID DRACP01831
Peptide Name PIER4 (Tat-PIER1)
Sequence GRKKRRQRRRPQ
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin AMPs
Type Synthetic peptide
Classification
Active ACP Cancer targeted peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| SK-BR-3 | Breast adenocarcinoma | Carcinoma | TAT-PIER1 dose-dependently killed a breast cancer cell line, SKBR3 | Flow cytometry | 12 h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Hsp90
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C65H124N34O15
Absent amino acids ACDEFHILMNSTVWY
Common amino acids R
Mass 181828
Pl 13.2
Basic residues 8
Acidic residues 0
Hydrophobic residues 0
Net charge 8
Boman Index -11076
Hydrophobicity -365
Aliphatic Index 0
Half Life
Mammalian: 7.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID WO2013/134116A1
Patent Title Hsp90 Inhibitor for the Treatment of Cancer and Inflammatory Diseases
Other Iinformation Patent Application; Family: 1s / 1ex; Family Jurisdictions: WO; Legal Status: Pending; Application No: 2013028852; Filed: Mar 4, 2013; Published: Sep 12, 2013; Earliest Priority: Mar 5, 2012
Other Published ID US201261606551P20120305
This work is licensed under a Creative Commons Attribution 4.0 International License.