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IL4RPep1KLA
General Information
DRACP ID DRACP01832
Peptide Name IL4RPep1KLA
Sequence CRKRLDRCGGGKLAKLAKKLAKLAK
Sequence Length 25
UniProt ID Not available
PubChem CID Not available
Origin Synthetics
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| 4T1 | Malignant neoplasms of the mouse mammary gland | Carcinoma | IC50=274.6 μM | Not available | Not available | Patent |
| 4T1 | Malignant neoplasms of the mouse mammary gland | Carcinoma | IC50=16.61 μM | Not available | Not available | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C118H221N41O28S2
Absent amino acids EFHIMNPQSTVWY
Common amino acids K
Mass 315473
Pl 11.46
Basic residues 10
Acidic residues 1
Hydrophobic residues 9
Net charge 9
Boman Index -5511
Hydrophobicity -57.2
Aliphatic Index 94
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 125
Absorbance 280nm 5.21
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID WO2017/003044A1
Patent Title Pharmaceutical Composition That Is Anticancer and Suppresses Cancer Metastasis, Containing, as Active Ingredient, Fusion Peptide Simultaneously Targeting Cancer Cell and Tumor Associated Macrophage
Other Iinformation Patent Application; Family: 6s / 6ex; Family Jurisdictions: KR, US, WO, JP; Legal Status: Pending; Application No: 2015012162; Filed: Nov 12, 2015; Published: Jan 5, 2017; Earliest Priority: Jun 30, 2015
Other Published ID JP2018521998A JP6720227B2 KR101741594B1 KR20170003203A US2018201651A1
This work is licensed under a Creative Commons Attribution 4.0 International License.