This work is licensed under a Creative Commons Attribution 4.0 International License.
RPS6 subunit anticancer peptide
General Information
DRACP ID DRACP01833
Peptide Name RPS6 subunit anticancer peptide
Sequence ISGGNDKQGFPM
Sequence Length 12
UniProt ID P47838 Q5E995 P62753 P39017 Q90YR8 Q9YGF2 Q2PQM1 Q9BMX5 O01727 P0CX37
PubChem CID Not available
Origin Synthetics
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Eca 109 | Esophageal squamous cell carcinoma; Squamous cell carcinoma of the esophagus | Carcinoma | The growth inhibition rate of human esophageal cancer Eca-109 cells is dose-dependent. It was found that the concentration of 0.8ug/ml had the best effect on the growth inhibition of human esophageal | MTT assay | 36 h | Patent |
| BCaP-37 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | Showed significant inhibition on the growth of human breast cancer Bcap-37 cells, and the optimal inhibition rate was 40.35% at the concentration of 15μg/ml. | MTT assay | 36 h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Human normal hepatocyte ChangLiver: At 36 hours, it had little effect on the growth inhibition of normal human hepatocytes ChangLiver (only weak growth inhibition or weak growth promotion)
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C53H83N15O18S
Absent amino acids ACEHLRTVWY
Common amino acids G
Mass 144678
Pl 6.34
Basic residues 1
Acidic residues 1
Hydrophobic residues 2
Net charge 0
Boman Index -1678
Hydrophobicity -73.33
Aliphatic Index 32.5
Half Life
Mammalian: 1.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID WO2017/049946A1
Patent Title Pharmaceutical Composition That Is Anticancer and Suppresses Cancer Metastasis, Containing, as Active Ingredient, Fusion Peptide Simultaneously Targeting Cancer Cell and Tumor Associated Macrophage
Other Iinformation Patent Application; Family: 6s / 6ex; Family Jurisdictions: KR, US, WO, JP; Legal Status: Pending; Application No: 2015012162; Filed: Nov 12, 2015; Published: Jan 5, 2017; Earliest Priority: Jun 30, 2015
Other Published ID JP2018521998A JP6720227B2 KR101741594B1 KR20170003203A US2018201651A1
This work is licensed under a Creative Commons Attribution 4.0 International License.