This work is licensed under a Creative Commons Attribution 4.0 International License.
ANS-1
General Information
DRACP ID DRACP01834
Peptide Name ANS-1
Sequence AVPSP
Sequence Length 5
UniProt ID Not available
PubChem CID Not available
Origin Synthetics
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | Cell proliferation was inhibit in a concentration-dependent manner (figure 2) | MTT assay | 36 h | Patent |
| SK-MEL-2 | Melanoma | Carcinoma | Cell proliferation was inhibit in a concentration-dependent manner (figure 2) | MTT assay | 36 h | Patent |
| HCT 116 | Colon carcinoma | Carcinoma | Cell proliferation was inhibit in a concentration-dependent manner (figure 2) | MTT assay | 36 h | Patent |
| SK-OV-3 | Ovarian serous cystadenocarcinoma | Carcinoma | Cell proliferation was inhibit in a concentration-dependent manner (figure 2) | MTT assay | 36 h | Patent |
| U-87MG ATCC | Glioblastoma | Blastoma | Cell proliferation was inhibit in a concentration-dependent manner (figure 2) | MTT assay | 36 h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HaCaT, NHDF: Almost no toxicity to normal cells (fig. 8)
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C21H35N5O7
Absent amino acids CDEFGHIKLMNQRTWY
Common amino acids P
Mass 54106
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 2
Net charge 0
Boman Index 245
Hydrophobicity 40
Aliphatic Index 78
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID WO2021/025352A1
Patent Title Anticancer Virus Expressing Fgf2- or Api5-Derived Peptide, and Use Thereof
Other Iinformation Patent Application; Family: 3s / 3ex; Family Jurisdictions: WO, KR; Legal Status: Pending; Application No: 2020009856; Filed: Jul 27, 2020; Published: Feb 11, 2021; Earliest Priority: Aug 8, 2019
Other Published ID KR102241134B1 KR20210017560A
This work is licensed under a Creative Commons Attribution 4.0 International License.