Varv Hm

General Information


DRACP ID  DRACP01838

Peptide Name   Varv Hm

Sequence  GLPVCGETCFGGTCNTPGCSCXTWPVCSRN

Sequence Length  30

UniProt ID  Not available

PubChem CID  Not available

Origin  Viola arvensis (European field pansy) (Field violet)

Type  Native peptide

Classification

  

Active ACP Membrane-targeted



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
BEL-7402 Human papillomavirus-related endocervical adenocarcinoma Carcinoma IC50>10 µg/ml SRB assay 48 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys5<--->Cys19; Cys9<--->Cys21; Cys14<--->Cys27

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  X=Glu-methylation

Chiral  L



Physicochemical Information


Formula  C120H183N35O39S6

Absent amino acids  ADHIKMQY

Common amino acids  C

Mass  355979

Pl  5.94

Basic residues  1

Acidic residues  1

Hydrophobic residues  5

Net charge  0

Boman Index  -2140

Hydrophobicity  9.67

Aliphatic Index  32.33

Half Life 
  /

Extinction Coefficient cystines  5875

Absorbance 280nm  202.59

Polar residues  19

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 20580652

Title  Isolation and characterization of cytotoxic cyclotides from Viola tricolor

Doi 10.1016/j.peptides.2010.05.004

Year  2010

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.