This work is licensed under a Creative Commons Attribution 4.0 International License.
Varv He
General Information
DRACP ID DRACP01839
Peptide Name Varv He
Sequence GLPVCGETCFGGTCNTPGCSCXTWPVCSRN
Sequence Length 30
UniProt ID Not available
PubChem CID Not available
Origin Viola arvensis (European field pansy) (Field violet)
Type Native peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| BEL-7402 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50>10 µg/ml | SRB assay | 48 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys5<--->Cys19; Cys9<--->Cys21; Cys14<--->Cys27
N-terminal Modification Free
C-terminal Modification Free
Other Modification X=Glu-ethylation
Chiral L
Physicochemical Information
Formula C120H183N35O39S6
Absent amino acids ADHIKMQY
Common amino acids C
Mass 355979
Pl 5.94
Basic residues 1
Acidic residues 1
Hydrophobic residues 5
Net charge 0
Boman Index -2140
Hydrophobicity 9.67
Aliphatic Index 32.33
Half Life
/
Extinction Coefficient cystines 5875
Absorbance 280nm 202.59
Polar residues 19
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 20580652
Title Isolation and characterization of cytotoxic cyclotides from Viola tricolor
Doi 10.1016/j.peptides.2010.05.004
Year 2010
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.