This work is licensed under a Creative Commons Attribution 4.0 International License.
CP-EPS8-NLS
General Information
DRACP ID DRACP01846
Peptide Name CP-EPS8-NLS
Sequence GRKKRRQRRRPQSKRKKNKKGKRK
Sequence Length 24
UniProt ID Not available
PubChem CID Not available
Origin Derived from the NLS of EPS8
Type Synthetic peptide
Classification
Active ACP EPS8/NLS inhibitors
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| KG-1a | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | ~45%Cellular viability=105 µM | CCK-8 assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C128H246N60O29
Absent amino acids ACDEFHILMTVWY
Common amino acids K
Mass 350013
Pl 13.36
Basic residues 17
Acidic residues 0
Hydrophobic residues 0
Net charge 17
Boman Index -18855
Hydrophobicity -353.33
Aliphatic Index 0
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29357910
Title A synthetic cell-penetrating peptide derived from nuclear localization signal of EPS8 exerts anticancer activity against acute myeloid leukemia
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.