MIA-690

General Information


DRACP ID  DRACP01849

Peptide Name   MIA-690

Sequence  YADAIFTNSYRKVLGQLSARKLLQDIMSR

Sequence Length  29

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP Hormone stimulating peptides GHRH antagonists



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HCT 15 Colon adenocarcinoma Carcinoma ~70%Inhibition=5 µM MTT assay 70-72 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP01849

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Phenylacetyl 12-aminododecanoyl

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C149H245N43O43S

Absent amino acids  CEHPW

Common amino acids  L

Mass  385853

Pl  10.44

Basic residues  5

Acidic residues  2

Hydrophobic residues  11

Net charge  3

Boman Index  -5881

Hydrophobicity  -22.07

Aliphatic Index  101.03

Half Life 
  Mammalian: 2.8 hour
  Yeast: 10 min
  E.coli: 2 min

Extinction Coefficient cystines  2980

Absorbance 280nm  106.43

Polar residues  8

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 28130121

Title  Synthesis and structure-activity studies on novel analogs of human growth hormone releasing hormone (GHRH) with enhanced inhibitory activities on tumor growth

Doi 10.1016/j.peptides.2017.01.009

Year  2017

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.