This work is licensed under a Creative Commons Attribution 4.0 International License.
MIA-690
General Information
DRACP ID DRACP01849
Peptide Name MIA-690
Sequence YADAIFTNSYRKVLGQLSARKLLQDIMSR
Sequence Length 29
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Hormone stimulating peptides GHRH antagonists
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HCT 15 | Colon adenocarcinoma | Carcinoma | ~70%Inhibition=5 µM | MTT assay | 70-72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Phenylacetyl 12-aminododecanoyl
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C149H245N43O43S
Absent amino acids CEHPW
Common amino acids L
Mass 385853
Pl 10.44
Basic residues 5
Acidic residues 2
Hydrophobic residues 11
Net charge 3
Boman Index -5881
Hydrophobicity -22.07
Aliphatic Index 101.03
Half Life
Mammalian: 2.8 hour
Yeast: 10 min
E.coli: 2 min
Extinction Coefficient cystines 2980
Absorbance 280nm 106.43
Polar residues 8
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28130121
Title Synthesis and structure-activity studies on novel analogs of human growth hormone releasing hormone (GHRH) with enhanced inhibitory activities on tumor growth
Doi 10.1016/j.peptides.2017.01.009
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.