JMR-132
General Information
DRACP ID DRACP01850
Peptide Name JMR-132
Sequence YADAIFTAXXHKVLGQLSAHKLLQDIMSR
Sequence Length 29
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Hormone stimulating peptides GHRH antagonists
Activity Information
Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
---|---|---|---|---|---|---|
LNCaP | Prostate carcinoma | Carcinoma | ~88%Inhibition=5 µM | MTT assay | 70-72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification X(9)=homoArg; X(10)=Tyr methyl ether
Chiral L
Physicochemical Information
Formula C136H216N38O36S
Absent amino acids CENPW
Common amino acids AL
Mass 371115
Pl 9.26
Basic residues 5
Acidic residues 2
Hydrophobic residues 12
Net charge 3
Boman Index -2630
Hydrophobicity 12.41
Aliphatic Index 104.48
Half Life
/
Extinction Coefficient cystines 1490
Absorbance 280nm 53.21
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28130121
Title Synthesis and structure-activity studies on novel analogs of human growth hormone releasing hormone (GHRH) with enhanced inhibitory activities on tumor growth
Doi 10.1016/j.peptides.2017.01.009
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available