This work is licensed under a Creative Commons Attribution 4.0 International License.
JMR-132
General Information
DRACP ID DRACP01850
Peptide Name JMR-132
Sequence YADAIFTAXXHKVLGQLSAHKLLQDIMSR
Sequence Length 29
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Hormone stimulating peptides GHRH antagonists
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| LNCaP | Prostate carcinoma | Carcinoma | ~88%Inhibition=5 µM | MTT assay | 70-72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification X(9)=homoArg; X(10)=Tyr methyl ether
Chiral L
Physicochemical Information
Formula C136H216N38O36S
Absent amino acids CENPW
Common amino acids AL
Mass 371115
Pl 9.26
Basic residues 5
Acidic residues 2
Hydrophobic residues 12
Net charge 3
Boman Index -2630
Hydrophobicity 12.41
Aliphatic Index 104.48
Half Life
/
Extinction Coefficient cystines 1490
Absorbance 280nm 53.21
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28130121
Title Synthesis and structure-activity studies on novel analogs of human growth hormone releasing hormone (GHRH) with enhanced inhibitory activities on tumor growth
Doi 10.1016/j.peptides.2017.01.009
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.