This work is licensed under a Creative Commons Attribution 4.0 International License.
Amurin-2a
General Information
DRACP ID DRACP01851
Peptide Name Amurin-2a
Sequence FLPLLLAGLPSFLCLVFKKC
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Rana amurensis
Type Native peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=302.1 µM | MTT assay | Not available | 1 |
Hemolytic Activity Horse erythrocytes: 50% Hemolysis=439.0 µM
Normal (non-cancerous) Cytotoxicity HMEC-1: IC50=1545 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys14<--->Cys20
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C110H176N22O22S2
Absent amino acids DEHIMNQRTWY
Common amino acids L
Mass 256196
Pl 8.82
Basic residues 2
Acidic residues 0
Hydrophobic residues 12
Net charge 2
Boman Index 3823
Hydrophobicity 169
Aliphatic Index 156
Half Life
Mammalian: 2.8 hour
Yeast: 10 min
E.coli: 2 min
Extinction Coefficient cystines 125
Absorbance 280nm 6.58
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29366784
Title Identification of novel Amurin-2 variants from the skin secretion of Rana amurensis, and the design of cationicity-enhanced analogues
Doi 10.1016/j.bbrc.2018.01.124
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.