Amurin-2a

General Information


DRACP ID  DRACP01851

Peptide Name   Amurin-2a

Sequence  FLPLLLAGLPSFLCLVFKKC

Sequence Length  20

UniProt ID  Not available

PubChem CID  Not available

Origin  Rana amurensis

Type  Native peptide

Classification

  

Active ACP Membrane-targeted



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
MCF-7 Invasive breast carcinoma of no special type Carcinoma IC50=302.1 µM MTT assay Not available 1

Hemolytic Activity  Horse erythrocytes: 50% Hemolysis=439.0 µM

Normal (non-cancerous) Cytotoxicity  HMEC-1: IC50=1545 µM

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial; Antifungal



Structure Information


PDB ID  Not available

Predicted Structure  DRACP01851

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys14<--->Cys20

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C110H176N22O22S2

Absent amino acids  DEHIMNQRTWY

Common amino acids  L

Mass  256196

Pl  8.82

Basic residues  2

Acidic residues  0

Hydrophobic residues  12

Net charge  2

Boman Index  3823

Hydrophobicity  169

Aliphatic Index  156

Half Life 
  Mammalian: 2.8 hour
  Yeast: 10 min
  E.coli: 2 min

Extinction Coefficient cystines  125

Absorbance 280nm  6.58

Polar residues  4

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 29366784

Title  Identification of novel Amurin-2 variants from the skin secretion of Rana amurensis, and the design of cationicity-enhanced analogues

Doi 10.1016/j.bbrc.2018.01.124

Year  2018

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.