This work is licensed under a Creative Commons Attribution 4.0 International License.
Amurin-2a [L4K]
General Information
DRACP ID DRACP01852
Peptide Name Amurin-2a [L4K]
Sequence FLPKLLAGLPSFLCLVFKKC
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=41.6 µM | MTT assay | Not available | 1 |
Hemolytic Activity Horse erythrocytes: 50% Hemolysis=31.0 µM
Normal (non-cancerous) Cytotoxicity HMEC-1: IC50=85.2 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys14<--->Cys20
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C110H177N23O22S2
Absent amino acids DEHIMNQRTWY
Common amino acids L
Mass 257697
Pl 9.67
Basic residues 3
Acidic residues 0
Hydrophobic residues 11
Net charge 3
Boman Index 2776
Hydrophobicity 130.5
Aliphatic Index 136.5
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 125
Absorbance 280nm 6.58
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29366784
Title Identification of novel Amurin-2 variants from the skin secretion of Rana amurensis, and the design of cationicity-enhanced analogues
Doi 10.1016/j.bbrc.2018.01.124
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.