This work is licensed under a Creative Commons Attribution 4.0 International License.
K(RW)3
General Information
DRACP ID DRACP01854
Peptide Name K(RW)3
Sequence KRWRWRW
Sequence Length 7
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HT-29 | Colon adenocarcinoma | Carcinoma | IC50=4.3 µM | Crystal violet assay | 48 h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis=114 µM
Normal (non-cancerous) Cytotoxicity Human fibroblasts: IC50=32.5 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification C8
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C57H80N20O8
Absent amino acids ACDEFGHILMNPQSTVY
Common amino acids RW
Mass 128058
Pl 12.81
Basic residues 4
Acidic residues 0
Hydrophobic residues 3
Net charge 4
Boman Index -4332
Hydrophobicity -287.14
Aliphatic Index 0
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 16500
Absorbance 280nm 2750
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24900420
Title Tuning the activity of a short arg-trp antimicrobial Peptide by lipidation of a C- or N-terminal lysine side-chain
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.