This work is licensed under a Creative Commons Attribution 4.0 International License.
Desotamide B [V2I]
General Information
DRACP ID DRACP01855
Peptide Name Desotamide B [V2I]
Sequence NIlLWG
Sequence Length 6
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Hep-G2 | Hepatoblastoma | Blastoma | IC50=606.8 µM | SRB assay | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Vero cells: IC50=90.8 µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Asn1<--->Gly6
N-terminal Modification Free
C-terminal Modification Free
Other Modification l=D-Leu
Chiral Mix
Physicochemical Information
Formula C29H41N7O6
Absent amino acids ACDEFHKMPQRSTVY
Common amino acids GILNW
Mass 67306
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 3
Net charge 0
Boman Index 647
Hydrophobicity 58.33
Aliphatic Index 130
Half Life
/
Extinction Coefficient cystines 5500
Absorbance 280nm 1100
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29125222
Title Total Synthesis and Antibacterial Study of Cyclohexapeptides Desotamide B, Wollamide B and Their Analogs
Year 2018
Literature 2
Pubmed ID 29431987
Title Solid-Phase Synthesis and Antibacterial Activity of Cyclohexapeptide Wollamide B Analogs
Doi 10.1021/acscombsci.7b00189
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.