This work is licensed under a Creative Commons Attribution 4.0 International License.
Wollamide B [D-Orn6Orn]
General Information
DRACP ID DRACP01856
Peptide Name Wollamide B [D-Orn6Orn]
Sequence NVlLWX
Sequence Length 6
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Hep-G2 | Hepatoblastoma | Blastoma | IC50=137.6 µM | SRB assay | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Vero cells: IC50=73.2 µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Asn1<--->X6
N-terminal Modification Free
C-terminal Modification Free
Other Modification l=D-Leu; X=Orn
Chiral Mix
Physicochemical Information
Formula C26H34N6O4
Absent amino acids ACDEFGHIKMPQRSTY
Common amino acids LNVWX
Mass 69396
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 3
Net charge 0
Boman Index 465
Hydrophobicity 60
Aliphatic Index 113.33
Half Life
/
Extinction Coefficient cystines 5500
Absorbance 280nm 1100
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29125222
Title Total Synthesis and Antibacterial Study of Cyclohexapeptides Desotamide B, Wollamide B and Their Analogs
Year 2018
Literature 2
Pubmed ID 29431987
Title Solid-Phase Synthesis and Antibacterial Activity of Cyclohexapeptide Wollamide B Analogs
Doi 10.1021/acscombsci.7b00189
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.