This work is licensed under a Creative Commons Attribution 4.0 International License.
Desotamide A
General Information
DRACP ID DRACP01857
Peptide Name Desotamide A
Sequence NGWLLI
Sequence Length 6
UniProt ID Not available
PubChem CID 10349738
Origin Streptomyces scopuliridis SCSIO ZJ46
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Hep-G2 | Hepatoblastoma | Blastoma | IC50>100 µM | SRB assay | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Asn1<--->Ile6
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C35H54N8O8
Absent amino acids ACDEFHKMPQRSTVY
Common amino acids L
Mass 80424
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 4
Net charge 0
Boman Index 1139
Hydrophobicity 121.67
Aliphatic Index 195
Half Life
Mammalian: 1.4 hour
Yeast: 3 min
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 1100
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25072108
Title Cyclic Hexapeptides from the Deep South China Sea-Derived Streptomyces scopuliridis SCSIO ZJ46 Active Against Pathogenic Gram-Positive Bacteria
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPN_11147
This work is licensed under a Creative Commons Attribution 4.0 International License.