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KFAK(7)
General Information
DRACP ID DRACP01880
Peptide Name KFAK(7)
Sequence KFAKKFAKKFAKKFAKKFAKKFAKKFAK
Sequence Length 28
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 13% Killing=500µg/ml | MTS assay | 24 h | Patent |
Hemolytic Activity RBCs: 13.7%Hemolysis=250 µg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C168H268N42O29
Absent amino acids CDEGHILMNPQRSTVWY
Common amino acids K
Mass 382201
Pl 11.91
Basic residues 14
Acidic residues 0
Hydrophobic residues 14
Net charge 14
Boman Index -4417
Hydrophobicity -80
Aliphatic Index 25
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US7091185B2
Patent Title Periodic antimicrobial peptides
Other Iinformation Granted Patent; Family: 2s / 2ex; Family Jurisdictions: US; Legal Status: Inactive; Application No: 78521004; Filed: Feb 24, 2004; Published: Aug 15, 2006; Earliest Priority: Feb 24, 2003; Granted: Aug 15, 2006
Other Published ID US2005187151A1
This work is licensed under a Creative Commons Attribution 4.0 International License.