This work is licensed under a Creative Commons Attribution 4.0 International License.
LL37 (14-21)+Cecropin-P1 (2-9), LC
General Information
DRACP ID DRACP01917
Peptide Name LL37 (14-21)+Cecropin-P1 (2-9), LC
Sequence GKEFKRIVWLSKTAKKL
Sequence Length 17
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Hep-G2 | Hepatoblastoma | Blastoma | Not active up to 128 µM | MTT assay | 20-24 h | 1 |
Hemolytic Activity Human erythrocytes: 5%Hemolysis>128 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C96H162N26O22
Absent amino acids CDHMNPQY
Common amino acids K
Mass 231807
Pl 11.37
Basic residues 6
Acidic residues 1
Hydrophobic residues 7
Net charge 5
Boman Index -2859
Hydrophobicity -55.29
Aliphatic Index 91.76
Half Life
Mammalian:
Yeast:
E.coli:
Extinction Coefficient cystines 5500
Absorbance 280nm 343.75
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29282543
Title Characterization of bactericidal efficiency, cell selectivity, and mechanism of short interspecific hybrid peptides
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_11171
This work is licensed under a Creative Commons Attribution 4.0 International License.