This work is licensed under a Creative Commons Attribution 4.0 International License.
LL37 (14-21)+Indolicidin (5-13), LI
General Information
DRACP ID DRACP01918
Peptide Name LL37 (14-21)+Indolicidin (5-13), LI
Sequence GKEFKRIVKWPWWPWRR
Sequence Length 17
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Hep-G2 | Hepatoblastoma | Blastoma | 87.5% Killing=128µM | MTT assay | 20-24 h | 1 |
Hemolytic Activity Human erythrocytes: 5%Hemolysis>128 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C117H167N33O20
Absent amino acids ACDHLMNQSTY
Common amino acids W
Mass 264137
Pl 12.26
Basic residues 6
Acidic residues 1
Hydrophobic residues 7
Net charge 5
Boman Index -4602
Hydrophobicity -143.53
Aliphatic Index 40
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 22000
Absorbance 280nm 1375
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29282543
Title Characterization of bactericidal efficiency, cell selectivity, and mechanism of short interspecific hybrid peptides
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_11172
This work is licensed under a Creative Commons Attribution 4.0 International License.