This work is licensed under a Creative Commons Attribution 4.0 International License.
LL37 (14-21)+NP-1 (23-31), LN
General Information
DRACP ID DRACP01919
Peptide Name LL37 (14-21)+NP-1 (23-31), LN
Sequence GKEFKRIVGRIYRLCCR
Sequence Length 17
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Hep-G2 | Hepatoblastoma | Blastoma | 80% Killing=128µM | MTT assay | 20-24 h | 1 |
Hemolytic Activity Human erythrocytes: 5%Hemolysis>128 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C92H157N31O21S2
Absent amino acids ADHMNPQSTW
Common amino acids R
Mass 238314
Pl 10.86
Basic residues 6
Acidic residues 1
Hydrophobic residues 5
Net charge 5
Boman Index -5151
Hydrophobicity -38.82
Aliphatic Index 85.88
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 1615
Absorbance 280nm 100.94
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29282543
Title Characterization of bactericidal efficiency, cell selectivity, and mechanism of short interspecific hybrid peptides
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_11173
This work is licensed under a Creative Commons Attribution 4.0 International License.