This work is licensed under a Creative Commons Attribution 4.0 International License.
Neutrophil antibiotic peptide NP-1
General Information
DRACP ID DRACP01920
Peptide Name Neutrophil antibiotic peptide NP-1
Sequence VTCYCRRTRCGFRERLSGACGYRGRIYRLCCR
Sequence Length 32
UniProt ID Q62716
PubChem CID Not available
Origin Rattus norvegicus
Type Native peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Hep-G2 | Hepatoblastoma | Blastoma | 20-25% Killing=16-256µM | MTT assay | 20-24 h | 1 |
Hemolytic Activity Human erythrocytes: 5%Hemolysis>128 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys3<--->Cys31; Cys5<--->Cys20; Cys10<--->Cys30
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C158H261N59O41S6
Absent amino acids DHKMNPQW
Common amino acids R
Mass 438865
Pl 9.94
Basic residues 9
Acidic residues 1
Hydrophobic residues 6
Net charge 8
Boman Index -11502
Hydrophobicity -49.38
Aliphatic Index 48.75
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 4845
Absorbance 280nm 156.29
Polar residues 16
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29282543
Title Characterization of bactericidal efficiency, cell selectivity, and mechanism of short interspecific hybrid peptides
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_11174
This work is licensed under a Creative Commons Attribution 4.0 International License.