This work is licensed under a Creative Commons Attribution 4.0 International License.
CRAMP (20-35)[G4W][K6R]
General Information
DRACP ID DRACP01924
Peptide Name CRAMP (20-35)[G4W][K6R]
Sequence KKIWQRIKNFFQKL
Sequence Length 14
UniProt ID P51437
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Hep-G2 | Hepatoblastoma | Blastoma | EC50=50µM | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C91H145N25O18
Absent amino acids ACDEGHMPSTVY
Common amino acids K
Mass 210937
Pl 12
Basic residues 5
Acidic residues 0
Hydrophobic residues 6
Net charge 5
Boman Index -3179
Hydrophobicity -93.57
Aliphatic Index 83.57
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 423.08
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30176261
Title Structure-activity relationship study of the antimicrobial CRAMP-derived peptide CRAMP20-33
Doi 10.1016/j.peptides.2018.08.013
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_12501
This work is licensed under a Creative Commons Attribution 4.0 International License.