Phylloseptin-PHa [A7K, V12I, A16I]

General Information


DRACP ID  DRACP01930

Peptide Name   Phylloseptin-PHa [A7K, V12I, A16I]

Sequence  FLSLIPKAISAISALINHF

Sequence Length  19

UniProt ID  A0A2I2KHV2 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
U-251MG Astrocytoma Carcinoma LD50=10.85 µM MTT assay Not available 1

Hemolytic Activity  Horse erythrocytes:50% Hemolysis=9.266µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial; Antifungal



Structure Information


PDB ID  Not available

Predicted Structure  DRACP01930

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C99H159N23O24

Absent amino acids  CDEGMQRTVWY

Common amino acids  I

Mass  237675

Pl  9.7

Basic residues  2

Acidic residues  0

Hydrophobic residues  12

Net charge  2

Boman Index  1878

Hydrophobicity  135.79

Aliphatic Index  159.47

Half Life 
  Mammalian: 1.1 hour
  Yeast: 3 min
  E.coli: 2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  4

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 30774309

Title  Structure-activity relationship of an antimicrobial peptide, Phylloseptin-PHa: balance of hydrophobicity and charge determines the selectivity of bioactivities

Doi 10.2147/DDDT.S191072

Year  2019

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_12628

DRACP is developed by Dr.Zheng's team.