This work is licensed under a Creative Commons Attribution 4.0 International License.
Phylloseptin-PHa [A7K, V12I, A16I]
General Information
DRACP ID DRACP01930
Peptide Name Phylloseptin-PHa [A7K, V12I, A16I]
Sequence FLSLIPKAISAISALINHF
Sequence Length 19
UniProt ID A0A2I2KHV2
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| U-251MG | Astrocytoma | Carcinoma | LD50=10.85 µM | MTT assay | Not available | 1 |
Hemolytic Activity Horse erythrocytes:50% Hemolysis=9.266µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C99H159N23O24
Absent amino acids CDEGMQRTVWY
Common amino acids I
Mass 237675
Pl 9.7
Basic residues 2
Acidic residues 0
Hydrophobic residues 12
Net charge 2
Boman Index 1878
Hydrophobicity 135.79
Aliphatic Index 159.47
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30774309
Title Structure-activity relationship of an antimicrobial peptide, Phylloseptin-PHa: balance of hydrophobicity and charge determines the selectivity of bioactivities
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_12628
This work is licensed under a Creative Commons Attribution 4.0 International License.