This work is licensed under a Creative Commons Attribution 4.0 International License.
Chionodracine [F1W; H4,15,17K; I9K; S11,21K]
General Information
DRACP ID DRACP01933
Peptide Name Chionodracine [F1W; H4,15,17K; I9K; S11,21K]
Sequence WFGKLYRGKTKVVKKVKGLLKG
Sequence Length 22
UniProt ID K4Q515
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| SH-SY5Y | 0% Killing=64 µM | CellTiter-Glo assay | Not available | 1 |
Hemolytic Activity Human erythrocytes: 5% Hemolysis=3µM; 30% Hemolysis=50µM
Normal (non-cancerous) Cytotoxicity HUVEC: 3.84% Killing=64 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C122H205N33O25
Absent amino acids ACDEHIMNPQS
Common amino acids K
Mass 290893
Pl 11.55
Basic residues 8
Acidic residues 0
Hydrophobic residues 8
Net charge 8
Boman Index -2053
Hydrophobicity -43.18
Aliphatic Index 92.73
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 6990
Absorbance 280nm 332.86
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30790604
Title Fish-derived antimicrobial peptides: Activity of a chionodracine mutant against bacterial models and human bacterial pathogens
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_12632
This work is licensed under a Creative Commons Attribution 4.0 International License.